Go to this thread.
Fourth post down there is a youtube video. Follow it EXPLICITLY(even using the directory structure of folder installation C:\Users\[Whatever the heck your user name is on your Win10 system]\Documents\My Games\Starfleet Command 2 Orion Pirates ). Even what boxes to tick post installation, including changing the Properties of StarfleetOP.exe, which is very important especially if you are running in windowed mode. And make sure you are shortcutting to the proper exe file (StarfleetOP.exe) to run the game, too.
Watch the video and do EXACTLY that.