Given what little substance we saw in the trailer. I can see a bit of a plot developing here. The Federation is out exploring and colonizing the outer regions, the frontier. The indigs get indignant and start fighting back. If Gene were still in charge of story telling, I'd say its an attempt to take a look at the United States' Westward Expansion days in the mid 1800s. It has potential to be a good story... but, potential. I don't trust anything coming from this branch of the Trek Universe.