SpaceX with the Falcons (1, 9 and 9 Heavy), Scaled Composites with SpaceShip One and Two and other companies may well revolutionize near space usage driving costs way down and usage way up. Hopefully they will and push NASA and other national space agencies back to basic research further out.
This might have happened sooner but for various international efforts to restrict private space travel. As I recall in the U.S. at one point a regulation was made requiring special permission for ANY rocket launch. After they were inundated with requests for permissions to launch model rockets they lightened up a little. I give a great deal of credit to the X-Prize competition for starting things off.
I really want to see some of the manufacturing in space that has been talked about for ages. I'd love to see a robotics firm team up with SpaceX and put their own robot moon base in place and start mining and manufacturing there.