Put the game directory back to the original location you installed to..
OR
Reinstall the game, patch, and then copy the game folder you are playing from in above pic and overwrite the new game install.. This will fix the registry entries.
If you want the game to play from a different directory, install the game again.. and during install, set path in installer to new location.. then patch, then copy old game folder on top of the new install.
this way you won't lose any mods..