OK.. any time you use an installer for the Starfleet Command games (SFC Installers) you have to have Anti-Virus turned off
Also, If you have any saved games, any updates tothe game means that you have to delete the saved games.
If you play a game, you have to make sure that you are either in Campaign mode or Conquest Mode and you have to pick 1 shiplist to play the game.. If you change Shiplists or Campaign modes, you will not be able to continue a previous saved game until you change your game back to the settings you had when you first started the saved game.