I saw someone asking for a fix for the single player campaign crashing and I figured out the problem.
Apparently the campaign scripts are installing improperly and need to be moved around.
On my computer under
C:\Games\Starfleet Command Orion Pirates\Assets\Scripts\Campaigns
it the "conquest" script package and the normal scripts in the same directory.
You need to move all the current scripts to another folder and make sure the following scripts are installed in the above directory.
BeastRaiders.mct
Camboro.mct
generalfederation.mct
generalgorn
generalhydran.mct
generalisc.mct
generalklingon.mct
generallyran.mct
generalmirak.mct
generalromulan.mct
korgath.mct
orion.mct
prime.mct
syndicate.mct
tigerheart.mct
wyldefire.mct
Those are all the default scripts that came with the game.
Also, make sure you are not playing using the OP Hardcore mod. I found that it made my campagins crash while the normal OP+ and Default Taldren mods worked fine.
Hope that helps.
bbarr97