Details Bearslayer, we need details!
... but my first guess would be the shortcut, make sure the working directory is present and correct. The easiest way to ensure this is to find StarFleetOP.exe in the installation folder, copy it and paste it
as a shortcut on the desktop, then run the game from this shortcut.
... second, try disabling windowed mode, I have found it is variable and just does not work on some hardware. The other possibility is that some other unknown application is stealing focus in the background and you are not seeing this (windowed mode is implicated here).
... OH wait! I remember! The intro video for many was a problem. The shortcut I outline above is the solution. Or
a full install of OP+4 also includes a shortcut fix to the game's normal start menu shortcut.
The other trick was sometimes to avoid this one could use the windows menu key to bring up the start menu and OP would minimize, then just click on some empty desktop and then restore the game running in the taskbar.
But just for the fun of it lets test me 'ol search script to see what it finds on 'Search result for "keyboard" in post subjects in all boards within the last decade':
Here's a good one (from the old Taldren forums):
http://www.dynaverse.net/forum/index.php/topic,163258826.0.htmlor (old forums again - shortcut again):
http://www.dynaverse.net/forum/index.php/topic,163180135.0.htmlor (again the old forums and the shortcut or forcing an application focus one way or another):
http://www.dynaverse.net/forum/index.php/topic,16354495.0.html... yup seems to still work ok... those dupes from the old forums gotta go tho, lotta dead weight there the original import (before my time) bugged, I think I could probably fix that with a little time and a few clever queries by now. (the search script would be even faster!
)
Anyway, I'm guessing that one of these common issues is your problem.
EDIT: P.S. note #3 here:
http://www.dynaverse.net/forum/index.php/topic,163359567.0.html