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Dr. Hidefumi Waki, working in a research group led by Professor Julian Paton, has found a novel role for the protein, JAM-1 (junctional adhesion molecule-1), which is located in the walls of blood vessels in the brain.JAM-1 traps white blood cells called leukocytes which, once trapped, can cause inflammation and may obstruct blood flow, resulting in poor oxygen supply to the brain. This has led to the idea that high blood pressure -- hypertension -- is an inflammatory vascular disease of the brain.One in three people in the UK are likely to develop hypertension, and with 600 million people affected world wide, it is of pandemic proportions. The alarming statistic that nearly 60 per cent of patients remain hypertensive, even though they are taking drugs to alleviate the condition, emphasises the urgency of looking for new mechanisms by which the body controls blood pressure, and finding new therapeutic targets to drive fresh drug development.