It Depends, If It's Windows 95-98 then Yes, However, Old DOS games are alot harder to get to run, I tried one awhile back, and eventually got It to go, But I forgot how.
Sometimes, what you need to do Is actually Do The Install in Compatibility mode.
For Example, You load up the CD for Game, and Go to D:\Game setup.
rright click on the setup, and run the Install in compatibility mode.
Then of course, Run everything else after the Game installs in the same Mode IE. The actual Exe file that starts the game, Not the shortcut itself.
BTW, What game are you trying, That might help abit.
Stephen