maybe the registy is telling it to look somewhere else, or maybe the registry doesn't have the right cd-key... a reinstall should fix this, or open the registry editor (start\run\regedit) and go to HKEY_LOCAL_MACHINE, then SOFTWARE, then Activision, then Star Trek Starfleet Command III. it will show you what drive it looks at at CD, and the cd-key is where it says KEY. To fix it if it is wrong, just double click on what you need to change and change the value data.