Imagine such a ship commanded by Spock, with a crew or Saavik, B'lana Torres, Worf's kid Alexander, and Tasha Yar's mean little girl for starters. Imagine they started a colony: a group with hard, pointy heads.
This also calls to mind the mysterious dead astronaut from one of the Enterprise episodes- a mix of primarily human DNA with Vulcan and some others the doctor couldn't identify! (I think T'Pol was actually offended!)